ALTercations at telomeres: stress, recombination and extrachromosomal affairs-Reference-Cited by-同舟云学术

ALTercations at telomeres: stress, recombination and extrachromosomal affairs

Published:2023-09-28 Issue:5 Volume:51 Page:1935-1946
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Loe Taylor K¹,Lazzerini Denchi Eros²,Tricola Gianna M.²,Azeroglu Benura²^ORCID

Affiliation:

1. 1Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, U.S.A.

2. 2Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, U.S.A.

Abstract

Approximately 15% of human cancers depend on the alternative lengthening of telomeres (ALT) pathway to maintain telomeres and proliferate. Telomeres that are elongated using ALT display unique features raising the exciting prospect of tailored cancer therapies. ALT-mediated telomere elongation shares several features with recombination-based DNA repair. Strikingly, cells that use the ALT pathway display abnormal levels of replication stress at telomeres and accumulate abundant extrachromosomal telomeric DNA. In this review, we examine recent findings that shed light on the ALT mechanisms and the strategies currently available to suppress this telomere elongation mechanism.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/doi/10.1042/BST20230265/951250/bst-2023-0265c.pdf

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