Affiliation:
1. Haematology Section, Clinical Research Centre, Harrow, Middlesex, and University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, London
Abstract
1. The isolated choroid plexus of the rabbit takes up 5-methyltetrahydrofolate from the incubation medium.
2. Other folate analogues (pteroylglutamic acid, methotrexate, 5-formyltetrahydrofolate = folinic acid) inhibited the uptake of 5-methyltetrahydrofolate.
3. The uptake of 5-methyltetrahydrofolate was inhibited by low temperature, anaerobic conditions and dinitrophenol.
4. The anticonvulsant drugs, diphenylhydantoin and phenobarbital, had no effect on 5-methyltetrahydrofolate uptake.
5. The inhibitory effect of pteroylglutamic acid on the uptake of 5-methyltetrahydrofolate by the choroid plexus may explain the effect of long-term folic acid therapy in aggravating vitamin B12 neuropathy in pernicious anaemia.
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1 articles.
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