Fate of haem iron in the malaria parasite Plasmodium falciparum-Reference-Cited by-同舟云学术

Fate of haem iron in the malaria parasite Plasmodium falciparum

Published:2002-07-15 Issue:2 Volume:365 Page:343-347
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

EGAN Timothy J.¹,COMBRINCK Jill M.²,EGAN Joanne²,HEARNE Giovanni R.³,MARQUES Helder M.⁴,NTENTENI Skhumbuzo³,SEWELL B. Trevor⁵,SMITH Peter J.²,TAYLOR Dale²,van SCHALKWYK Donelly A.²,WALDEN Jason C.²

Affiliation:

1. Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa

2. Department of Medicine, Division of Pharmacology, University of Cape Town, Private Bag, Rondebosch 7701, South Africa

3. School of Physics, University of the Witwatersrand, PO Wits 2050, Johannesburg, South Africa

4. School of Chemistry, University of the Witwatersrand, PO Wits 2050, Johannesburg, South Africa

5. Electron Microscope Unit, University of Cape Town, Private Bag, Rondebosch 7701, South Africa

Abstract

Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2% of the iron within parasitized erythrocytes, of which 92±6% is located within the food vacuole. Of this, 88±9% is in the form of haemozoin. 57Fe-Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/365/2/343/709143/bj3650343.pdf

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