Affiliation:
1. Aix Marseille University, CNRS, IBDM (UMR 7288), Turing Centre for Living Systems, Marseille, France
Abstract
Gastruloids acquire their organization and shape through cell biochemical and mechanical activities. Such activities determine the physical forces and changes in material properties that transform simple spherical aggregates into organized tissues. In this Perspective, we discuss why the concepts and approaches of mechanobiology, a discipline that focuses on cell and tissue mechanics and its contribution to the organization and functions of living systems, are essential to the gastruloid field and, in turn, what gastruloids may teach us about mechanobiology.
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology