Sequence studies of the Fd section of the heavy chain of rabbit immunoglobulin G

Author:

Fruchter R. G.1,Jackson S. A.1,Mole L. E.1,Porter R. R.1

Affiliation:

1. Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, U.K.

Abstract

A partial amino acid sequence was given by Cebra, Steiner & Porter (1968b) of the N-terminal half of the heavy chain of rabbit immunoglobulin G. This was extended and in part corrected to give a continuous sequence of 136 residues, which together with other work accounts for three-quarters of the total sequence. Evidence is given suggesting that there is a limited region of 10–15 residues that are exceptionally variable in the heavy chains from pooled rabbit immunoglobulin G.

Publisher

Portland Press Ltd.

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1. Antibody Binding Sites;Antigen Binding Molecules: Antibodies and T-cell Receptors;1996

2. Structural Studies of Immunoglobulins;Scandinavian Journal of Immunology;1991-10

3. Comparison of Theoretical and Experimental Determinations of cis/trans Proline Isomer Ratios: Effect of Molecular Charge State;Australian Journal of Chemistry;1989

4. Immunoglobulin Genetics;Structure of Membranes and Receptors;1984

5. Nucleotide sequence of a rabbit IgG heavy chain from the recombinant F-I haplotype;Immunogenetics;1983-10

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