The relationship between Fas and Fas ligand gene polymorphism and preeclampsia risk

Author:

Wang Tingting1,Lian Yunyun1ORCID

Affiliation:

1. Department of Gynaecology and Obstetrics, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China

Abstract

Abstract Preeclampsia is an idiopathic multisystem disorder with partial genetic and immunological etiology. Several studies investigated the association between various single-nucleotide polymorphisms (SNPs) in Fas and Fas ligand (FasL) genes and the risk of preeclampsia. However, they achieved inconsistent results. Therefore, we conducted a meta-analysis by systematically searching the Cochrane Library, PubMed and Embase databases and assessed this association by calculating pooled odds ratios with 95% confidence interval to reach a more trustworthy conclusion. Subgroup analyses by genotype methods and source of controls (SOC) were also conducted. Seven citations containing nine studies were included for four SNPs (Fas -670 A/G, FasL 124A/G, FasL -844C/T, Fas -1377 G/A) in this meta-analysis. Our data suggested the G allele and genotype GG of the Fas -670 A/G polymorphism, GG genotype of the FasL 124A/G polymorphism, and TT genotype of the FasL -844C/T polymorphism increased the risk of preeclampsia. Stratification analyses by genotype methods and SOC also indicated that Fas -670 A/G polymorphism was related to increased risk for preeclampsia. In conclusion, Fas and FasL gene polymorphisms play important roles in the development of preeclampsia. Further well-designed studies in other races are needed to confirm the findings of this meta-analysis.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference24 articles.

1. Pre-eclampsia;Mol;Lancet,2016

2. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy;American College of O., Gynecologists and Task Force on Hypertension in P;Obstet. Gynecol.,2013

3. An essay of reflection: Why does preeclampsia exist in humans, and why are there such huge geographical differences in epidemiology;Robillard;J. Reprod. Immunol.,2016

4. Regulatory T cells in embryo implantation and the immune response to pregnancy;Robertson;J. Clin. Invest.,2018

5. Histone deacetylase inhibition disturbs the balance between ACE and chymase expression in endothelial cells: a potential mechanism of chymase activation in preeclampsia;Wang;Hypertens. Res.,2018

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