Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels

Author:

Alstrom Jette Skov1,Stroemlund Line Waring2,Nielsen Morten Schak2,MacAulay Nanna1

Affiliation:

1. Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark

2. Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Biomedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark

Abstract

Connexin43 (Cx43) generates intercellular gap junction channels involved in, among others, cardiac and brain function. Gap junctions are formed by the docking of two hemichannels from neighbouring cells. Undocked Cx43 hemichannels can upon different stimuli open towards the extracellular matrix and allow transport of molecules such as fluorescent dyes and ATP. A range of phosphorylated amino acids have been detected in the C-terminus of Cx43 and their physiological role has been intensively studied both in the gap junctional form of Cx43 and in its hemichannel configuration. We present the current knowledge of protein kinase C (PKC)-dependent regulation of Cx43 and discuss the divergent results.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Reference50 articles.

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