The PTEN protein: cellular localization and post-translational regulation

Author:

Leslie Nick R.1,Kriplani Nisha1,Hermida Miguel A.1,Alvarez-Garcia Virginia1,Wise Helen M.1

Affiliation:

1. Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh EH14 4AS, U.K.

Abstract

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the growth and proliferation of many cell types. It has been heavily studied, in large part due to its status as a tumour suppressor, the loss of function of which is observed through diverse mechanisms in many tumour types. Here we present a concise review of our understanding of the PTEN protein and highlight recent advances, particularly in our understanding of its localization and regulation by ubiquitination and SUMOylation.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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