Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain (Short Communication)-Reference-Cited by-同舟云学术

Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain (Short Communication)

Published:1973-03-15 Issue:3 Volume:132 Page:653-656
ISSN:0306-3283
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Buckley Brendan M.¹,Williamson Dermot H.¹

Affiliation:

1. Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, U.K.

Abstract

The existence of acetoacetyl-CoA synthetase in rat brain cytosol is reported. The coupling of this enzyme with cytosolic acetoacetyl-CoA thiolase can provide acetyl-CoA for lipogenesis and cholesterol synthesis without the need for mitochondrial participation. This new route for acetoacetate utilization may be important in developing brain.

Publisher

Portland Press Ltd.

Link

https://portlandpress.com/biochemj/article-pdf/132/3/653/780295/bj1320653.pdf

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