GPX4: old lessons, new features-Reference-Cited by-同舟云学术

GPX4: old lessons, new features

Published:2022-06-27 Issue:3 Volume:50 Page:1205-1213
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Nishida Xavier da Silva Thamara¹,Friedmann Angeli José Pedro¹,Ingold Irina²

Affiliation:

1. 1Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany

2. 2Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany

Abstract

GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell death was essential for understanding the conditions that determine GPX4 dependency and ultimately to the process of lipid peroxidation. Since its discovery, ferroptosis has been gaining momentum as a promising target for yet-incurable diseases, including cancer and neurodegeneration. Given the current interest, in the present review, we provide newcomers in the field with an overview of the biology of GPX4 and cover some of its most recent discoveries.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/50/3/1205/934329/bst-2022-0682c.pdf

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