Mre11–Rad50: the DNA end game-Reference-Cited by-同舟云学术

Mre11–Rad50: the DNA end game

Published:2023-03-09 Issue:2 Volume:51 Page:527-538
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Hopfner Karl-Peter¹²^ORCID

Affiliation:

1. 1Gene Center, Ludwig-Maximilians-Universität Munich, Munich, Germany

2. 2Department of Biochemistry, Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-Universität Munich, Munich, Germany

Abstract

The Mre11–Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of life. It is an intricate DNA associated molecular machine that cuts, among other functions, a large variety of free and obstructed DNA termini for DNA repair by end joining or homologous recombination, yet leaves undamaged DNA intact. Recent years have brought progress in both the structural and functional analyses of Mre11–Rad50 orthologs, revealing mechanisms of DNA end recognition, endo/exonuclease activities, nuclease regulation and DNA scaffolding. Here, I review our current understanding and recent progress on the functional architecture Mre11–Rad50 and how this chromosome associated coiled-coil ABC ATPase acts as DNA topology specific endo-/exonuclease.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/51/2/527/945806/bst-2022-0754c.pdf

Reference132 articles.

1. The DNA damage response: making it safe to play with knives;Mol. Cell,2010

2. The DNA-damage response in human biology and disease;Nature,2009

3. Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine;Science,2004

4. The molecular basis and disease relevance of non-homologous DNA end joining;Nat. Rev. Mol. Cell Biol.,2020

5. Homologous recombination and the repair of DNA double-strand breaks;J. Biol. Chem.,2018

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms;Nature Communications;2024-08-22

2. Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres;Nucleic Acids Research;2024-06-17

3. Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP;Molecular Cell;2024-06

4. A novel Mre11 protein from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5 possesses 5′–3′ exonuclease and endonuclease activities;International Journal of Biological Macromolecules;2024-06

5. DNA sensing of dendritic cells in cancer immunotherapy;Frontiers in Molecular Biosciences;2024-05-22