Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells-Reference-Cited by-同舟云学术

Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells

Published:2014-01-23 Issue:1 Volume:42 Page:189-194
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Viswanatha Raghuvir¹,Bretscher Anthony¹,Garbett Damien¹

Affiliation:

1. Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, U.S.A.

Abstract

Microvilli are found on the apical surface of epithelial cells. Recent studies on the microvillar proteins ezrin and EBP50 (ezrin/radixin/moesin-binding phosphoprotein of 50 kDa) have revealed both the dynamics and the regulation of microvillar components, and how a dynamic ezrin phosphocycle is necessary to confine microvilli to the apical membrane. In the present review, we first summarize the background to allow us to place these advances in context.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/42/1/189/484741/bst0420189.pdf

Reference65 articles.

1. Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells;Bretscher;J. Cell Biol.,1983

2. Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor;Bretscher;J. Cell Biol.,1989

3. Microvillus-specific Mr 75,000 plasma membrane protein of human choriocarcinoma cells;Pakkanen;J. Histochem. Cytochem.,1987

4. Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells;Berryman;J. Cell Sci.,1993

5. Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane–cytoskeletal linker;Algrain;J. Cell Biol.,1993

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