The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites

Author:

Yadav Shweta1,Cockcroft Shamshad2,Raghu Padinjat1

Affiliation:

1. National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India

2. Department of Neuroscience, Physiology and Pharmacology, University College, London WC1E 6JJ, U.K.

Abstract

Several recent studies have demonstrated the existence of membrane contact sites (MCS) between intracellular organelles in eukaryotic cells. Recent exciting studies have also demonstrated the existence of biomolecular interactions at these contact sites in mediating changes in the membrane composition of the cellular compartments. However, the role of such contact sites in regulating organelle function and physiological processes remains less clear. In this review we discuss the existence of a contact site between the plasma membrane (PM) and the endoplasmic reticulum (ER) in Drosophila photoreceptors. Further, we discuss the role of specific proteins present at this location in regulating phospholipid turnover and its impact in regulating a physiological process, namely phototransduction.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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