Affiliation:
1. Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.
Abstract
Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural and functional characteristics of the family of CRH-like peptides and their receptors.
Cited by
50 articles.
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