Inhibition of leucyl-transfer ribonucleic acid synthetase in Bacillus subtilis by Granaticin-Reference-Cited by-同舟云学术

Inhibition of leucyl-transfer ribonucleic acid synthetase in Bacillus subtilis by Granaticin

Published:1975-12-01 Issue:3 Volume:152 Page:511-515
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Ogilvie A¹,Wiebauer K¹,Kersten W¹

Affiliation:

1. Physiologisch-Chemisches Institut 1, Universität Erlangen, 8520 Erlangen, W. Germany

Abstract

The bacteriostatic effect of low concentrations of the antibiotic granaticin on Bacillus subtilis is relieved by the addition leucine to the growth medium. In cells treated with granaticin, aminoacylation of leucine tRNA is specifically decreased, but the content of free leucine is not. It is concluded that granaticin interferes with the charging process of leucine tRNA in B. subtilis leading to leucine auxotrophy.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/152/3/511/566066/bj1520511.pdf

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