Affiliation:
1. Cardiovascular Research Institute and Department of Anesthesia, University of California, San Francisco Medical Center, San Francisco, Calif. 94122, U.S.A.
Abstract
Sudden oxygenation of a thin film of rat brain homogenate, suspended between the surface of a glass pH-sensitive electrode and a gas-permeable membrane, is accompanied by a fall in pH, which is greater when carbonic anhydrase is inhibited. The result suggests that oxidative decarboxylation yields carbonic acid (HCO3− and H+), which dissociates to form molecular carbon dioxide. Brain carbonic anhydrase facilitates the formation of carbon dioxide from the decarboxylation products.
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51 articles.
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