Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens-Reference-Cited by-同舟云学术

Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens

Published:2018-12-17 Issue:1 Volume:47 Page:229-238
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Turner Natasha C.A.¹,Connolly James P.R.¹,Roe Andrew J.¹^ORCID

Affiliation:

1. Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, U.K.

Abstract

Abstract Enterohaemorrhagic Escherichia coli (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly controlled by master regulators. This system is further modulated by a number of signals that help to fine-tune virulence, including metabolic, environmental and chemical signals. Since the LEE and its master regulator, Ler, were established, there have been numerous scientific advancements in understanding the regulation and expression of virulence factors in EHEC. This review will discuss the recent advancements in this field since our previous review, with a focus on the transcriptional regulation of the LEE.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/47/1/229/848600/bst-2018-0546c.pdf

Reference93 articles.

1. Pathogenic Escherichia coli;Nat. Rev. Microbiol.,2004

2. Enteropathogenic and enterohemorrhagic Escherichia coli virulence gene regulation;Infect. Immun.,2007

3. Enteropathogenic Escherichia coli: unravelling pathogenesis;FEMS Microbiol. Rev.,2005

4. Escherichia coli cytotoxin, haemolytic-uraemic syndrome, and haemorrhagic colitis;Lancet,1983

5. Escherichia coli O157:H7 gastroenteritis and the hemolytic uremic syndrome: an emerging infectious disease;Annu. Rev. Med.,1999

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