Affiliation:
1. School of Biology, Faculty of Biology Medicine and Health, University of Manchester, Michael Smith Building, Manchester M13 9PL, U.K.
Abstract
CFTR (ABCC7) is a phospho-regulated chloride channel that is found in the apical membranes of epithelial cells, is gated by ATP and the activity of the protein is crucial in the homeostasis of the extracellular liquid layer in many organs [Annu. Rev. Biochem. (2008) 77, 701–726; Science (1989) 245, 1066–1073]. Mutations in CFTR cause the inherited disease cystic fibrosis (CF), the most common inherited condition in humans of European descent [Science (1989) 245, 1066–1073; Pflugers Arch. (2007) 453, 555–567]. The structural basis of CF will be discussed in this article.
Cited by
14 articles.
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