Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo-Reference-Cited by-同舟云学术

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

Published:1991-07-15 Issue:2 Volume:277 Page:573-576
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Anderson N G¹,Li P¹,Marsden L A²,Williams N¹,Roberts T M²,Sturgill T W¹

Affiliation:

1. *Departments of Internal Medicine and Pharmacology, University of Virginia, Charlottesville, VA 2290.

2. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, U.S.A.

Abstract

MAP (mitogen-activated protein) kinase is shown to phosphorylate baculovirally expressed Raf-1 in vitro, generating one major tryptic phosphopeptide which co-migrated with a peptide from Raf-1 32P-labelled in situ. This peptide also undergoes an insulin-dependent increase in labelling. Thus the serine/threonine kinase Raf-1 may be a substrate for MAP kinase in vivo.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/277/2/573/604250/bj2770573.pdf

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