Involvement of d-amino acid oxidase in elimination of free d-amino acids in mice-Reference-Cited by-同舟云学术

Involvement of d-amino acid oxidase in elimination of free d-amino acids in mice

Published:1989-01-01 Issue:1 Volume:257 Page:291-292
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Nagata Y¹,Konno R²,Yasumura Y²,Akino T¹

Affiliation:

1. Department of Biochemistry, Sapporo Medical College, Sapporo 060, Japan

2. Department of Microbiology, Dokkyo University School of Medicine, Mibu, Tochigi 321-02, Japan

Abstract

The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/257/1/291/594876/bj2570291.pdf

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