Angiotensin Receptors - Affinity and Beyond

Author:

Sumners Colin1ORCID,Souza Silva Igor Maciel2,Steckelings U. Muscha2ORCID

Affiliation:

1. 1Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, U.S.A.

2. 2Department of Cardiovascular & Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark

Abstract

Abstract This commentary on the article “Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors” by Sanja Bosnyak et al. (Clini. Sci. (Lond.) (2011) 121(7): 297–303. https://doi.org/10.1042/CS20110036) summarises the main findings of the study, followed by a discussion of the findings and their relevance for various aspects of the biology of receptors of the renin-angiotensin system in the context of the current state of knowledge.

Publisher

Portland Press Ltd.

Subject

General Medicine

Reference20 articles.

1. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors;Bosnyak;Clin. Sci. (Lond.),2011

2. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors;Kemp;Hypertension,2012

3. Angiotensin III: a central regulator of vasopressin release and blood pressure;Reaux;Trends Endocrinol. Metab.,2001

4. Evolution of a new class of antihypertensive drugs: targeting the brain renin-angiotensin system;Llorens-Cortes;Hypertension,2020

5. International union of pharmacology. XXIII. The angiotensin II receptors;de Gasparo;Pharmacol. Rev.,2000

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