A Study of Zinc Metabolism in Alcoholic Cirrhosis-Reference-Cited by-同舟云学术

A Study of Zinc Metabolism in Alcoholic Cirrhosis

Published:1983-05-01 Issue:5 Volume:64 Page:527-535
ISSN:0143-5221
Container-title:Clinical Science
language:en
Short-container-title:

Author:

Mills Peter R.¹,Fell Gordon S.¹²,Bessent Rodney G.¹³⁴,Nelson Lesley M.¹,Russell Robin I.¹

Affiliation:

1. Gastroenterology Unit, Glasgow, Scotland, U.K.

2. Departments of Biochemistry, Glasgow, Scotland, U.K.

3. Departments of Nuclear Medicine, Glasgow Royal Infirmary, Glasgow, Scotland, U.K.

4. West of Scotland Health Boards Department of Clinical Physics and Bioerigineering, Glasgow, Scotland, U.K.

Abstract

1. Zinc metabolism was studied in 11 patients with alcoholic cirrhosis and 13 healthy volunteers using the isotope tracer 65Zn. 2. Intestinal absorption, whole-body content and total daily elimination of zinc were all increased in alcoholic cirrhosis, but the biological half-life of zinc did not differ from controls. 3. Hepatic zinc concentration was reduced in alcoholic cirrhosis and correlated with changes in hepatic alcohol dehydrogenase activity. 4. Patients with alcoholic cirrhosis in this study were not demonstrated to be zinc-deficient.

Publisher

Portland Press Ltd.

Subject

General Medicine

Link

https://portlandpress.com/clinsci/article-pdf/64/5/527/454103/cs0640527.pdf

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