Classical activation of macrophages and vardenafil-Reference-Cited by-同舟云学术

Classical activation of macrophages and vardenafil

Published:2017-05-22 Issue:11 Volume:131 Page:1141-1145
ISSN:0143-5221
Container-title:Clinical Science
language:en
Short-container-title:

Author:

Muimo Richmond¹

Affiliation:

1. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield, U.K.

Abstract

Inhibitors of phosphodiesterase 5 (PDE5) – sildenafil citrate (Viagra; Pfizer) and vardenafil hydrochloride (Levitra; Bayer/GlaxoSmithKline) – approved for the treatment of erectile dysfunction and pulmonary arterial hypertension also rescue the loss of cystic fibrosis (CF) chloride channel function and the mislocalization of F508del-CFTR in affected tissues in CF. Can PDE5 inhibitors provide a therapeutic strategy which combines ability to correct the basic ion transport defect and to control de-regulated lung inflammation in CF?

Publisher

Portland Press Ltd.

Subject

General Medicine

Link

https://portlandpress.com/clinsci/article-pdf/131/11/1141/449250/cs-2017-0137c.pdf

Reference41 articles.

1. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond;Ghofrani;Nat. Rev. Drug Discovery,2006

2. Tadalafil in the treatment of erectile dysfunction;Coward;Ther. Clin. Risk Manag.,2008

3. Advances in targeting cyclic nucleotide phosphodiesterases;Maurice;Nat. Rev. Drug Discover.,2014

4. Mechanisms of disease: cystic fibrosis;Rowe;N. Engl. J. Med.,2005

5. Strategies in early clinical development for the treatment of basic defects of cystic fibrosis;Dhooghe;Expert Opin. Investig. Drugs,2016

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