Affiliation:
1. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5120, U.S.A.
Abstract
The E7 proteins of ‘low-risk’ and ‘high-risk‘ human papillomaviruses (HPV) are phosphorylated by casein kinase II. In this study, we report that the ‘low-risk’ HPV 6 E7 protein, but not the ‘high-risk’ HPV 16 E7 protein, can be phosphorylated in vitro on threonine at amino acid position 7 by protein kinase C. This is the first example of a qualitative biochemical difference between the HPV 6 E7 and HPV 16 E7 proteins.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
11 articles.
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