prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2-Reference-Cited by-同舟云学术

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

Published:1996-05-15 Issue:1 Volume:316 Page:25-28
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

SMYTH Miriam J.¹²,PERRY David K.³,ZHANG Jiandi⁴,POIRIER Guy G.⁵,HANNUN Yusuf A.³,OBEID Lina M.¹²

Affiliation:

1. Department of Medicine and Division of Geriatrics, Duke University Medical Center, Durham, NC 27710, U.S.A.

2. Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Durham, NC, U.S.A.

3. Department of Medicine and Division of Hematology/Oncology, Duke University Medical Center, Durham, NC 27710, U.S.A.

4. Department of Cell Biology, Duke University, Durham, NC 27710, U.S.A.

5. Poly(ADP-Ribose) Metabolism Group, Laboratory of Molecular Endocrinology, Centre Hospitalier de l'Université Laval Research Center and Laval University, Sainte-Foy, Quebec G1V 4G2, Canada

Abstract

The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bcl-2 protects from cell death.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/316/1/25/620201/bj3160025.pdf

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