Global translation variations in host cells upon attack of lytic and sublytic Staphylococcus aureus α-haemolysin

Author:

Clamer Massimiliano12,Tebaldi Toma1,Marchioretto Marta2,Bernabò Paola2,Bertini Efrem1,Guella Graziano3,Serra Mauro Dalla2,Quattrone Alessandro1,Viero Gabriella12

Affiliation:

1. Laboratory of Translational Genomics, Centre for Integrative Biology, University of Trento, via delle Regole, 101 38122 Mattarello, Trento, Italy

2. CNR Institute of Biophysics & Bruno Kessler Foundation, via alla Cascata 56/C, 38123 Trento, Italy

3. Department of Physics, University of Trento, via Sommarive 14, 38123 Povo, Trento, Italy

Abstract

Genome-wide analyses of translation can provide major contributions in our understanding of the complex interplay between virulent factors and host cells. So far, the activation of host translational control mechanisms by bacterial toxins, owing to specific recruitment of mRNAs, RNA-binding proteins (RBPs) and ncRNAs (non-coding RNAs), are far from being understood. In the present study, we characterize for the first time the changes experienced by the translational control system of host cells in response to the well-known Staphylococcus aureus α-haemolysin (AHL) under both sublytic and lytic conditions. By comparing variations occurring in the cellular transcriptome and translatome, we give evidence that global gene expression is primarily rewired at the translational level, with the contribution of the RBP ELAVL1 (HuR) in the sublytic response. These results reveal the importance of translational control during host–pathogen interaction, opening new approaches for AHL-induced diseases.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

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