Modelling Alzheimer’s disease in a dish: dissecting amyloid-β metabolism in human neurons-Reference-Cited by-同舟云学术

Modelling Alzheimer’s disease in a dish: dissecting amyloid-β metabolism in human neurons

Published:2024-01 Issue:1 Volume:8 Page:
ISSN:2059-6553
Container-title:Neuronal Signaling
language:en
Short-container-title:

Author:

Hill Elizabeth¹,Cunningham Thomas J.¹^ORCID

Affiliation:

1. MRC Prion Unit at UCL, Institute of Prion Diseases, Courtauld Building, London W1W 7FF, U.K.

Abstract

Abstract This scientific commentary refers to ‘Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition’ by Rowland et al. (https://doi.org/10.1042/NS20230016). Insulin-degrading enzyme (IDE) and neprilysin (NEP) have been proposed as two Aβ-degrading enzymes supported by human genetics and in vivo data. Rowland et al. provide complementary evidence of a key role for IDE in Aβ metabolism in human-induced pluripotent stem cell (iPSC)-derived cortical neurons.

Funder

UKRI | MRC | Medical Research Foundation

Publisher

Portland Press Ltd.

Subject

Cellular and Molecular Neuroscience

Link

https://portlandpress.com/neuronalsignal/article-pdf/doi/10.1042/NS20230020/953465/ns-2023-0020c.pdf

Reference15 articles.

1. Evidence for genetic linkage of Alzheimer’s disease to chromosome 10q;Bertram;Science (New York, NY,2000

2. Age at onset in two common neurodegenerative diseases is genetically controlled;Li;Am. J. Hum. Genet.,2002

3. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme;Vekrellis;J. Neurosci.: Off. J. Soc. Neurosci.,2000

4. Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo;Farris;Proc. Natl. Acad. Sci.,2003

5. Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death;Leissring;Neuron,2003