MIR100HG: a credible prognostic biomarker and an oncogenic lncRNA in gastric cancer

Author:

Li Jun1,Xu Qingfeng2,Wang Wen3,Sun Shaojun4ORCID

Affiliation:

1. Department of Clinical Laboratory, Jining NO. 1 People’s Hospital; Affiliated Jining NO. 1 People’s Hospital of Jining Medical University, Jining Medical University, Jining 272011, Shandong, China

2. Department of Hematology-Oncology, People’s Hospital of Gaotang County Affiliated to Jining Medical University, Liaocheng 252800, Shandong, China

3. Department of Clinical Laboratory, People’s Hospital of Binzhou City, Binzhou 256600, Shandong, China

4. Department of Clinical Laboratory, Brain Hospital of Liaocheng City, People’s Hospital of Liaocheng City, Liaocheng 252000, Shandong, China

Abstract

Abstract The MIR100HG expression was observed to be up-regulated or down-regulated in human cancer tissues depending on tumor types. However, there was no report about the role of MIR100HG in gastric cancer. In our study, we first found levels of MIR100HG expression were increased in gastric cancer cell lines and tissue samples compared with normal gastric epithelial cell line and adjacent normal gastric mucosa tissue samples, respectively. Moreover, high MIR100HG expression was positively associated with clinical stage, tumor invasion, lymph node metastasis, and distant metastasis in gastric cancer patients. Survival analysis showed MIR100HG expression was negative correlated with clinical outcome in gastric cancer patients from The Cancer Genome Atlas (TCGA) database or our study, and high MIR100HG expression served as an independent poor prognostic factor for gastric cancer patient’s overall survival. The study in vitro suggested down-regulation of MIR100HG expression inhibits cell proliferation, migration, and invasion in gastric cancer. In conclusion, MIR100HG is a credible prognostic biomarker and functions as an oncogenic lncRNA in gastric cancer.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

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