Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents-Reference-Cited by-同舟云学术

Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents

Published:2004-10-26 Issue:6 Volume:32 Page:959-961
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Bryant H.E.¹,Helleday T.¹

Affiliation:

1. The Institute for Cancer Studies, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, U.K.

Abstract

PARP [poly(ADP-ribose) polymerase] activity is up-regulated by binding to DNA strand breaks and its association with DNA repair is well documented. Many anticancer therapies work by inducing breaks in DNA, if unrepaired these can lead to cell death. As PARP promotes DNA repair there is a strong rational to suggest that its inhibition may increase the efficiency of certain cytotoxic treatments. This review discusses the advances made in PARP inhibitor design and the mechanism by which they enhance anti-tumour therapies.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/32/6/959/512347/bst0320959.pdf

Reference15 articles.

1. The world according to PARP

2. 3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity

3. Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

4. Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors

Cited by 47 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Therapeutic targeting of DNA damage repair pathways guided by homologous recombination deficiency scoring in ovarian cancers;Fundamental & Clinical Pharmacology;2022-10-08

2. Regulation and pharmacological targeting of RAD51 in cancer;NAR Cancer;2020-09-01

3. Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review;Bioorganic & Medicinal Chemistry;2019-09

4. Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice;International Journal of Molecular Medicine;2017-07-03

5. SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTICANCER EVALUATION OF NOVEL BENZO[D]IMIDAZOLE DERIVATIVES;International Journal Of Pharmaceutical Sciences And Research;2017-07-01