Zebularine: a new drug for epigenetic therapy-Reference-Cited by-同舟云学术

Zebularine: a new drug for epigenetic therapy

Published:2004-10-26 Issue:6 Volume:32 Page:910-912
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Yoo C.B.¹,Cheng J.C.¹,Jones P.A.¹

Affiliation:

1. Departments of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, 1441 Eastlake Ave., Los Angeles, CA 90089-9176, U.S.A.

Abstract

Regulatory genes are often hypermethylated at their promoter 5′ regions and silenced in cancer. Epigenetic therapy with DNA methylation inhibitors have been shown to result in the demethylation and reactivation of these genes. Zebularine is a recently discovered mechanism-based inhibitor of DNA methylation, and has received much attention for its potential in clinical use. Further studies exploring the effectiveness of zebularine in a variety of settings could allow the development of novel therapies for cancer.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/32/6/910/512426/bst0320910.pdf

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