Competitive resource allocation to metabolic pathways contributes to overflow metabolisms and emergent properties in cross-feeding microbial consortia

Author:

Carlson Ross P.1,Beck Ashley E.1,Phalak Poonam2,Fields Matthew W.1,Gedeon Tomas1,Hanley Luke3,Harcombe William R.4,Henson Michael A.2,Heys Jeffrey J.1

Affiliation:

1. Department of Chemical and Biological Engineering, Center for Biofilm Engineering, Microbiology and Immunology, or Mathematics, Montana State University, Bozeman, MT 59717, U.S.A.

2. Department of Chemical Engineering and the Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA 01003, U.S.A.

3. Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, U.S.A.

4. Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, MN 55108, U.S.A.

Abstract

Resource scarcity is a common stress in nature and has a major impact on microbial physiology. This review highlights microbial acclimations to resource scarcity, focusing on resource investment strategies for chemoheterotrophs from the molecular level to the pathway level. Competitive resource allocation strategies often lead to a phenotype known as overflow metabolism; the resulting overflow byproducts can stabilize cooperative interactions in microbial communities and can lead to cross-feeding consortia. These consortia can exhibit emergent properties such as enhanced resource usage and biomass productivity. The literature distilled here draws parallels between in silico and laboratory studies and ties them together with ecological theories to better understand microbial stress responses and mutualistic consortia functioning.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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