Catalysis by the nucleolytic ribozymes-Reference-Cited by-同舟云学术

Catalysis by the nucleolytic ribozymes

Published:2011-03-22 Issue:2 Volume:39 Page:641-646
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Lilley David M.J.¹

Affiliation:

1. Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

Abstract

The nucleolytic ribozymes use general acid–base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/39/2/641/548124/bst0390641.pdf

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