Affiliation:
1. Institute of Child Health, University of London, 30 Guilford Street, London, W.C. 1
Abstract
1. Four substances from the urine of a hypertensive newborn girl were partially characterized and shown to be 17α-hydroxy-5β-pregnane-1,3,20-trione, 3α,17α-dihydroxy-5β-pregnane-1,20-dione, 3α,17α,20α-trihydroxy-5β-pregnan-1-one and 5β-pregnane-1β,3α,17α,20α-tetrol. 2. The characterization rested mainly on RM analysis of the substances and their derivatives by glycol fission, providing evidence for position and degree of substitution and for steroidal character. Supporting evidence was provided by chemically specific location reactions. 3. Certain problems in the manipulation of these β-disubstituted steroids are discussed.
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Reduction of 1-oxo-steroids;Tetrahedron;1995-05
2. Partial characterization of unusual polar steroids in the urine of a child with low renin hypertension;Journal of Steroid Biochemistry;1982-03
3. Microbial synthesis of 1 beta- and 15 beta-hydroxylated bile acids.;Journal of Lipid Research;1981-11
4. 3α-Acetylthio-5α-androstan-17-one;Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry;1979-10-01
5. Catabolism of the Adrenocortical Hormones;General, Comparative and Clinical Endocrinology of the Adrenal Cortex;1978