Role of Epac in brain and heart-Reference-Cited by-同舟云学术

Role of Epac in brain and heart

Published:2012-01-19 Issue:1 Volume:40 Page:51-57
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Laurent Anne-Coline¹²³,Breckler Magali¹²³,Berthouze Magali¹²,Lezoualc'h Frank¹²

Affiliation:

1. Inserm, UMR-1048, Institut des Maladies Métaboliques et Cardiovasculaires, F-31342 Toulouse, France

2. Université de Toulouse III-Paul Sabatier, F-31342 Toulouse, France

3. Université Paris-Sud 11, Paris, France

Abstract

Epacs (exchange proteins directly activated by cAMP) are guanine-nucleotide-exchange factors for the Ras-like small GTPases Rap1 and Rap2. Epacs were discovered in 1998 as new sensors for the second messenger cAMP acting in parallel to PKA (protein kinase A). As cAMP regulates many important physiological functions in brain and heart, the existence of Epacs raises many questions regarding their role in these tissues. The present review focuses on the biological roles and signalling pathways of Epacs in neurons and cardiac myocytes. We discuss the potential involvement of Epacs in the manifestation of cardiac and central diseases such as cardiac hypertrophy and memory disorders.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/40/1/51/486912/bst0400051.pdf

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