DNA structure, nucleosome placement and chromatin remodelling: a perspective

Author:

Travers Andrew A.12,Vaillant Cédric3,Arneodo Alain3,Muskhelishvili Georgi4

Affiliation:

1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K.

2. Department of Biochemistry, Tennis Court Road, Cambridge CB2 1GA, U.K.

3. Laboratoire Joliot Curie, ENS de Lyon, Lyon, France

4. Jacobs University Bremen, School of Engineering and Science, Campus Ring 1, D-28759 Bremen, Germany

Abstract

A major question in chromatin biology is to what extent the sequence of DNA directly determines the genetic and chromatin organization of a eukaryotic genome? We consider two aspects to this question: the DNA sequence-specified positioning of nucleosomes and the determination of NDRs (nucleosome-depleted regions) or barriers. We argue that, in budding yeast, while DNA sequence-specified nucleosome positioning may contribute to positions flanking the regions lacking nucleosomes, DNA thermodynamic stability is a major component determinant of the genetic organization of this organism.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Reference51 articles.

1. DNA information: from digital code to analogue structure;Travers;Philos. Trans. R. Soc. London Ser. A,2012

2. The exocyclic groups of DNA modulate the affinity and positioning of the histone octamer;Buttinelli;Proc. Natl. Acad. Sci. U.S.A.,1998

3. Sequence periodicities in chicken nucleosome core DNA;Satchwell;J. Mol. Biol.,1986

4. A genomic code for nucleosome positioning;Segal;Nature,2006

5. Crystal structure of the nucleosome core particle at 2.8 Å resolution;Luger;Nature,1997

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