Mousing around with caspases and IAPs-Reference-Cited by-同舟云学术

Mousing around with caspases and IAPs

Published:2012-03-27 Issue:2 Volume:443 Page:e1-e2
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Rickert Robert C.¹,Salvesen Guy S.¹,Ware Carl F.¹

Affiliation:

1. Programs in Cell Death and Inflammation Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, U.S.A.

Abstract

In a paper in this issue of the Biochemical Journal that questions the role of c-IAP1 (cellular inhibitor of apoptosis 1) in inflammation, new results from the Duckett laboratory remind us of the importance of truly knowing the mice we depend on. It turns out that c-IAP1 is tightly linked to caspase 11 and cannot be segregated by recombination. This disturbing result implies that immune functions ascribed to c-IAP1 may be due to the caspase 11 mutation that is co-inherited with the locus.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/443/2/e1/673014/bj443e001.pdf

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