Extracellular vesicles in carcinoma microenvironment

Author:

Carvalho-Silva Larissa Tinô de12,Normando Ana Gabriela C.12,Sá Jamile de Oliveira1,dos Santos Erison Santana12,De Rossi Tatiane1,Busso-Lopes Ariane Fidelis1,de Oliveira Ana Karina3,Paes Leme Adriana F.1ORCID

Affiliation:

1. 1Laboratório Nacional de Biociências - LNBio, Centro Nacional de Pesquisa em Energia e Materiais - CNPEM, Campinas, SP 13083-100, Brazil

2. 2Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (UNICAMP), Piracicaba, SP 13414-903, Brazil

3. 3Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, 22908, United States

Abstract

Cancer is a significant cause of death, precluding increasing life expectancy worldwide. That is a multifactorial disease initiated by intrinsic or extrinsic factors that induce cell differentiation into cancer cells. However, cancer development, progression, and metastasis are not controlled only by cancer cells. The entire environment around these cells, named tumor microenvironment (TME), influences tumor development and spread. The tumor microenvironment is formed by cancer cells and heterogenous nonmalignant cells integrated with a complex extracellular matrix. The main cellular components of the TME are cancer-associated fibroblasts (CAFs), T lymphocytes, B cells, tumor-associated macrophages (TAMs), dendritic cells (DC), natural killer (NK) cells, tumor-associated neutrophils (TANs), Stem Cells, Endothelial Cells and their soluble secreted extracellular vesicles (EVs) that modulate cancer cells to establish and disseminate. This review provides a recent insight into the role of EVs secreted from different populations of the TME associated with the initiation and progression of carcinoma.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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