Sub-micromolar concentrations of extramitochondrial Ca2+ stimulate the rate of citrulline synthesis by rat liver mitochondria-Reference-Cited by-同舟云学术

Sub-micromolar concentrations of extramitochondrial Ca2+ stimulate the rate of citrulline synthesis by rat liver mitochondria

Published:1989-01-01 Issue:1 Volume:257 Page:285-288
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Johnston J D¹,Brand M D¹

Affiliation:

1. Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K.

Abstract

1. In the presence of physiological concentrations of Na+ and Mg2+, the rate of citrulline synthesis by isolated rat liver mitochondria respiring on a range of substrates was stimulated by up to 60% when the extramitochondrial Ca2+ concentration was raised from 130 pM to 770 nM. 2. Our findings suggest that hormonal stimulation of the urea cycle may be mediated by Ca2+.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/257/1/285/594796/bj2570285.pdf

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