Physiological roles of PKB/Akt isoforms in development and disease-Reference-Cited by-同舟云学术

Physiological roles of PKB/Akt isoforms in development and disease

Published:2007-03-20 Issue:2 Volume:35 Page:231-235
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Dummler B.¹,Hemmings B.A.¹

Affiliation:

1. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland

Abstract

PKB (protein kinase B, also known as Akt) is a serine/threonine protein kinase that is important in various signalling cascades and acts as a major signal transducer downstream of activated phosphoinositide 3-kinase. There are three closely related isoforms of PKB in mammalian cells, PKBα (Akt1), PKBβ (Akt2) and PKBγ (Akt3), and this review discusses recent advances in our understanding of the functions of these isoforms in the regulation of adipocyte differentiation, glucose homoeostasis and tumour development.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/35/2/231/542536/bst0350231.pdf

Reference37 articles.

1. Physiological functions of protein kinase B/Akt

2. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

3. PKBα is required for adipose differentiation of mouse embryonic fibroblasts

4. Protein Kinase B/AKT 1 Plays a Pivotal Role in Insulin-like Growth Factor-1 Receptor Signaling Induced 3T3-L1 Adipocyte Differentiation

5. The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

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