Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine-Reference-Cited by-同舟云学术

Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine

Published:2004-10-26 Issue:5 Volume:32 Page:733-737
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Wintermeyer W.¹,Peske F.¹,Beringer M.²,Gromadski K.B.²,Savelsbergh A.¹,Rodnina M.V.²

Affiliation:

1. Institute of Molecular Biology, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany

2. Institute of Physical Biochemistry, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany

Abstract

Protein synthesis in the cell is performed on ribosomes, large ribonucleoprotein particles, which in bacteria consist of three RNA molecules and over 50 proteins. This review summarizes recent progress in understanding the mechanisms of the elongation phase of protein synthesis. Results from rapid kinetic analysis of elongation reactions are discussed in the light of recent structural data.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/32/5/733/537352/bst0320733.pdf

Reference44 articles.

1. Initiation Factors in the Early Events of mRNA Translation in Bacteria

2. The Structural Basis of Large Ribosomal Subunit Function

3. Making sense of mimic in translation termination

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