Sensitivity analysis: from model parameters to system behaviour

Abstract

Sensitivity analysis addresses the manner in which model behaviour depends on model parametrization. Global sensitivity analysis makes use of statistical tools to address system behaviour over a wide range of operating conditions, whereas local sensitivity analysis focuses attention on a specific set of nominal parameter values. This narrow focus allows a complete analytical treatment and straightforward interpretation in the local case. Sensitivity analysis is a valuable tool for model construction and interpretation, and can be applied in medicine and biotechnology to predict the effect of interventions.