Stimulation of steroid glucuronidation by uridine diphosphate N-acetylglucosamine and by microsomal disruption-Reference-Cited by-同舟云学术

Stimulation of steroid glucuronidation by uridine diphosphate N-acetylglucosamine and by microsomal disruption

Published:1977-10-15 Issue:1 Volume:168 Page:125-127
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Wilkinson J,Hallinan T

Abstract

Glucuronidation of oestrone and of oestradiol in microsomal fractions was markedly and significantly stimulated by UDP-N-acetylglucosamine and by ultrasonication: Triton X-100 also stimulated. This is consistent with compartmentation of UDP-glucuronyl-transferase. Stimulation by UDP-N-acetylglucosamine may be physiologically significant.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/168/1/125/568747/bj1680125.pdf

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1. Modulation of UDP-Glucuronosyltransferase Activity by Endogenous Compounds;Drug Metabolism and Pharmacokinetics;2010

2. Evidence indicating that UDP-N-acetylglucosamine does not appear to stimulate hepatic microsomal UDP-glucuronosyltransferase by interaction with the catalytic unit of the enzyme;Biochimica et Biophysica Acta (BBA) - Biomembranes;1983-11

3. Comparison of different activators and diazotization procedures in the assay of bilirubin-UDP-glucuronyl transferase activity in rat liver;Clinica Chimica Acta;1983-03

4. Diazobenzenesulphonate selectively abolishes stimulation of glucuronidation by UDP-N-acetylglucosamine;Biochemical Journal;1980-12-15

5. Compartmentation of Uridine Diphosphate Glucuronosyltransferase: Effect of Uridine Diphosphate N-Acetylglucosamine on the Apparent V of glucuronidation;Biochemical Society Transactions;1978-02-01