ABC transporters involved in drug resistance in human parasites

Author:

Leprohon Philippe1,Légaré Danielle1,Ouellette Marc1

Affiliation:

1. Centre de Recherche en Infectiologie, CHUQ (Centre Hospitalier Universitaire de Québec) (Pavillon Centre Hospitalier de l'Université Laval), 2705 Boul. Laurier, Quebec City, QC, Canada, G1V 4G2, and Division de Microbiologie, Faculté de Médecine, Université Laval, Québec, QC, Canada, G1V 4G2

Abstract

The ABC (ATP-binding cassette) protein superfamily is a ubiquitous and functionally versatile family of proteins that is conserved from archaea to humans. In eukaryotes, most of these proteins are implicated in the transport of a variety of molecules across cellular membranes, whereas the remaining ones are involved in biological processes unrelated to transport. The biological functions of several ABC proteins have been described in clinically important parasites and nematode worms and include vesicular trafficking, phospholipid movement, translation and drug resistance. This chapter reviews our current understanding of the role of ABC proteins in drug resistance and treatment failure in apicomplexan, trypanosomatid and amitochondriate parasites of medical relevance as well as in helminths.

Publisher

Portland Press Ltd.

Subject

Molecular Biology,Biochemistry

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