Author:
Wojcikiewicz R J,Dobson P R,Irons L I,Robinson A,Brown B L
Abstract
Pertussis toxin (PT) caused the ADP-ribosylation of a Mr-41 000 protein in GH3-cell plasma-membrane preparations. This effect, and muscarinic inhibition of prolactin release, were reversed at similar rates by pretreatment of intact cells with PT. These results suggest that the Mr-41 000 protein is modified in intact GH3 cells, and that this protein (a component of the putative Ni unit of adenylate cyclase) is involved in the expression of muscarinic inhibition.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
27 articles.
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