A Detailed Study of the Urinary Peptides in a Patient with Osteomalacia and Hyperparathyroidism

Author:

Cahill Rose1,Smith R.1,Westall R. G.1

Affiliation:

1. Medical Unit, University College Hospital Medical School, London

Abstract

1. The urinary peptides and amino acids have been examined in a 28-year-old female with osteomalacia and severe parathyroid bone disease. Forty ninhydrin positive substances were identified. 2. These substances included nine hydroxyproline containing peptides of relatively simple composition. Of these eight contained 4-hydroxyproline, two contained cis-3-hydroxyproline and one had trans-3-hydroxyproline. Two larger peptides which contained a high proportion of 4-hydroxyproline residues were also found. Free 4-hydroxyproline, free hydroxylysine and a hydroxylysine complex were found. 3. Of the remaining twenty-six substances, which may not be derived from collagen, alaninol is reported as an urinary constituent for the first time, six are less common but have been reported previously whilst the remaining nineteen are well-known urinary constituents. 4. The significance of these findings in relation to collagen breakdown is discussed.

Publisher

Portland Press Ltd.

Subject

General Medicine

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Mouse models of the laminopathies;Experimental Cell Research;2007-06

2. Prolidase deficiency: a case report and literature review;British Journal of Dermatology;1989-09

3. Clinical and biochemical characteristics of prolidase deficiency in siblings;American Journal of Medical Genetics;1984-11

4. Polymorphism of urinary 4-hydroxyproline-containing polypeptides;Journal of Chromatography B: Biomedical Sciences and Applications;1981-09

5. a case of an exceptionally high level of urinary-4-hydroxyproline containing polypeptides;Clinica Chimica Acta;1981-01

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