OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study-Reference-Cited by-同舟云学术

OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study

Published:2019-02 Issue:2 Volume:39 Page:
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Shang Houlai¹,Hao Yuedong¹,Hu Wenhao¹,Hu Xiaohui¹,Jin Qing²^ORCID

Affiliation:

1. Department of Orthopaedics, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, Jiangsu, China

2. Department of Operation and Anesthesiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, Jiangsu, China

Abstract

Abstract Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case–control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). Results: The present study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) < 25 kg/m2 groups. Conclusions: To sum up, the present study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20182023/844633/bsr-2018-2023.pdf

Reference24 articles.

1. The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee;Michael;Dtsch. Arztebl. Int.,2010

2. Prevalence of symptomatic knee, hand, and hip osteoarthritis in Greece. The ESORDIG study;Andrianakos;J. Rheumatol.,2006

3. Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration;Miyatake;BMC Musculoskelet. Disord.,2016

4. Pathogenesis and epidemiology of osteoarthritis;Racine;R. I. Med. J.,2013

5. Osteoarthritis and its management - epidemiology, nutritional aspects and environmental factors;Bortoluzzi;Autoimmun. Rev.,2018

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology;Biomolecules;2023-03-09

2. Osteopontin, a bridge links osteoarthritis and osteoporosis;Frontiers in Endocrinology;2022-10-28

3. The Expression of αvβ3 and Osteopontin in Osteoarthritic Knee Cartilage and Their Correlations With Disease Severity and Chondrocyte Senescence;Applied Immunohistochemistry & Molecular Morphology;2022-09-20

4. Val109Asp Polymorphism of the Omentin-1 Gene and Incidence of Knee Osteoarthritis in a Chinese Han Population: A Correlation Analysis;Drug Design, Development and Therapy;2021-12

5. Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease;Biomedicines;2021-11-02