Affiliation:
1. MRC Mineral Metabolism Unit, The General Infirmary, Leeds, U.K.
2. Department of Chemical Pathology, The General Infirmary, Leeds, U.K.
Abstract
1. Studies were carried out on six normal male subjects to determine the short-term effect of increasing the dietary consumption of animal protein on the urinary risk factors for stone-formation, namely, volume, pH, calcium, oxalate, uric acid and glycosaminoglycans.
2. An increase of 34 g/day of animal protein in the diet significantly increased urinary calcium (23%) and oxalate (24%). Total urinary nitrogen increased by an average of 368 mmol/day. The accompanying increase in dietary purine (11 mmol of purine nitrogen/day) caused a 48% increase in the excretion of uric acid.
3. The overall relative probability of forming stones, calculated from a combination of the risk factors, was markedly increased (250%) throughout the period of high animal protein ingestion.
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