The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis

Author:

Feng Qianyun12,Zheng Sheng23,Zheng Jia1

Affiliation:

1. Department of Endocrinology, Peking Unversity First Hospital, Beijing, China

2. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China

3. Department of Spine Surgery, Tianjin Union Medical Center, Tianjin Institute of Spine, Tianjin, China

Abstract

Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may be the underlying mechanisms that link genetic and environmental factors with increased risks of osteoporosis and bone fracture. MicroRNA (miRNA), a major category of small noncoding RNA with 20–22 bases in length, is recognized as one important epigenetic modification. It can mediate post-transcriptional regulation of target genes with cell differentiation and apoptosis. In this review, we aimed to profile the role of miRNA in bone remodeling and its therapeutic implications for osteoporosis. A deeper insight into the role of miRNA in bone remodeling and osteoporosis can provide unique opportunities to develop a novel diagnostic and therapeutic approach of osteoporosis.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference78 articles.

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