Antisense oligonucleotides targeting angiotensinogen: insights from animal studies-Reference-Cited by-同舟云学术

Antisense oligonucleotides targeting angiotensinogen: insights from animal studies

Published:2019-01 Issue:1 Volume:39 Page:
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Wu Chia-Hua¹²,Wang Ya¹³,Ma Murong¹²,Mullick Adam E.⁴,Crooke Rosanne M.⁴,Graham Mark J.⁴,Daugherty Alan¹²⁵,Lu Hong S.¹²⁵

Affiliation:

1. Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, U.S.A.

2. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, U.S.A.

3. The Second Affiliated Hospital, Cardiovascular Key Laboratory of Zhejiang Province, Department of Cardiology, College of Medicine, Zhejiang University, Hangzhou, China

4. Ionis Pharmaceuticals, Inc., Carlsbad, CA, U.S.A.

5. Department of Physiology, University of Kentucky, Lexington, KY, U.S.A.

Abstract

Abstract Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and pathophysiological roles mediated by AGT.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20180201/844267/bsr-2018-0201c.pdf

Reference66 articles.

1. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators;Yusuf;N. Engl. J. Med.,2000

2. Telmisartan, ramipril, or both in patients at high risk for vascular events;Yusuf;N. Engl. J. Med.,2008

3. Translating molecular discoveries into new therapies for atherosclerosis;Rader;Nature,2008

4. Renin-angiotensin system and cardiovascular functions;Wu;Arterioscler. Thromb. Vasc. Biol.,2018

5. Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease;Ferrario;Pharmacol. Res.,2017

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