Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf-Reference-Cited by-同舟云学术

Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf

Published:2015-04-17 Issue:3 Volume:467 Page:425-438
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Samadani Ramin¹,Zhang Jun¹,Brophy Amanda¹,Oashi Taiji¹,Priyakumar U. Deva¹,Raman E. Prabhu¹,St John Franz J.¹,Jung Kwan-Young¹,Fletcher Steven¹,Pozharski Edwin¹,MacKerell Alexander D.¹,Shapiro Paul¹

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, U.S.A.

Abstract

Using virtual screening and biological assays, we have identified and characterized a new class of compounds that selectively inhibit the proliferation of cancer cells containing constitutively active kinase signalling pathways by targeting kinase regulation of oncogenic transcription factors.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/467/3/425/681950/bj4670425.pdf

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